Ukpds Lancet 1998 //
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UK Prospective Diabetes Study UKPDS Group. Lancet. 1998;352:837-853. Risk Reduction % P =.000054 P =.015 P =.052 P =.0099 P =.029 0 5 10 15 20 25 30 35 Diabetes-related end points Myocardial infarction Albuminuria Retinopathy Microvascular 25% 21% 16% 33% 12% UKPDS Intensive Treatment Policy and Risk Reduction. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes UKPDS 33. Lancet. 1998 Sep 12;352:837-53. UKPDS Riduzione del rischio di complicanze microvascolari UK Prospective Diabetes Study UKPDS Group. Lancet. 1998;352:837-853, with permission. % pazienti con un evento Gruppo trattamento intensivo 25% riduzione rischio globale P =.0099 Convenzionale Intensiva 03 6 0 10 20 30 912 15 Tempo dalla randomizzazione anni. The United Kingdom Prospective Diabetes Study UKPDS was a prospective, multi-centre cohort study, held across 23 hospitals in the UK over 20 years, examining the rates of micro- and macrovascular complications in patients who, in 1976, had recently been diagnosed with Type 2 Diabetes Mellitus. 5,102 patients had taken part in the study, with. Metformin is a widely used oral glucose-lowering drug for type 2 diabetes. The use of biguanide as a first-line drug depends on evidence showing that metformin reduces incidence of cardiovascular events as well as total mortality, in mega-trials of T2DM such as the UK Prospective Diabetes Study UKPDS UKPDS, 1998.

Prior to UKPDS, the University Group Diabetes Program UGDP, the only large-scale RCT to investigate the role of glycemic control on macrovascular outcomes in T2DM, demonstrated no macrovascular benefit with sulfonylureas. However, it revealed an unexpected increase in cardiovascular mortality with the sulfonylrea tolbutamine.

UKPDSの血圧コントロール試験に参加した患者において,厳格な血圧コントロールによる細小血管障害および大血管障害リスク低下が試験終了10年後にも継続しているかを検討した。UKPDSのpost-trial monitoring試験。 Holman RR, et al. N Engl J Med 2008; 359: 1565-76.</plaintext></p> <p>12/09/1998 · Objective: To determine whether tight control of blood pressure prevents macrovascular and microvascular complications in patients with type 2 diabetes. Design: Randomised controlled trial comparing tight control of blood pressure aiming at a blood pressure of <150/85 mm Hg with the use of an angiotensin converting enzyme inhibitor. DIABETES-STUDIE UKPDS ERGEBNISSE UND FOLGEN FÜR DIE PRAXIS: Gute Blutzucker- und Blutdruckkontrolle wirkt sich günstig auf die Prognose bei jüngeren Diabetikern aus. Dieses Ergebnis steht im Vordergrund der mit Spannung erwarteten größten und längsten Therapiestudie zum nicht insulinpflichtigen Typ 2-Diabetes mellitus, der UKPDS vgl.</p> <p>UKPDSが計画された当時には、2型糖尿病において厳格な血糖コントロールが合併症を抑制するかどうかは知られていませんでした。それどころか当時の唯一の大規模研究であったUGDPUniversity Group Diabetes Program. UKPDS 33. Lancet. 1998;352:837-853. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes UKPDS 34 Author links open overlay panel UK Prospective Diabetes Study. The UKPDS studied metformin primarily in obese patients,. 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